PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
Article Abstract:
This article analyzes the functions of peroxisome proliferator-activated receptor-gamma (PPAR) in macrophages, and also studies how the nuclear receptor is targeted by the thiazolidinedione set of antidiabetic drugs. Findings suggest that PPAR-gamma is not essential to, nor impacts, the development of macrophages, yet it is important to the regulation of the receptor CD36.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Muscle-specific Pparg deletion causes insulin resistance
Article Abstract:
A strain of mice with muscle-specific deletion of Pparg, the gene encoding PPAR-delta, is developed by using Cre-loxP gene targeting system. The findings indicated that muscle PPAR-delta expression play crucial role in skeletal muscle insulin sensitivity and Thiazolidinediones (TZD) action and may exert indirect effects on insulin action in adipose tissue and liver.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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PPARs and the complex journey to obesity
Article Abstract:
The 3 lipid-sensing peroxisome proliferator-activated receptors, PPAR-alpha, PPAR-gamma, PPAR-delta, regulate diverse aspects of lipid and glucose homeostasis. Link between glucose and lipid metabolism is presented with the role of PPARs as bonafide therapeutic targets.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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