Pathophysiologically based treatment interventions in schizophrenia
Article Abstract:
The contributions of disturbances in glutamate, dopamine and GABA neurotransmission to the pathophysiology of working memory impairments in schizophrenia are considered. A cascade of molecular events that may link these disturbances are suggested and an argument that the molecular alterations most proximal to the pathophysiology of prefrontal dysfunction offer the most promise as targets for new drug development is presented.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Pathophysiologically based treatment interventions in schizophrenia
Article Abstract:
The contributions of disturbances in glutamate, dopamine and GABA neurotransmission to the pathophysiology of working memory impairments in schizophrenia are considered. A cascade of molecular events that may link these disturbances are suggested and it is argued that the molecular alterations most proximal to the pathophysiology of prefrontal dysfunction offer the most promise as targets for new drug development.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Mutations in antiquitin in individuals with pyridoxine-dependent seizures
Article Abstract:
Pyridoxal 5'-phosphate (PLP) is an essential cofactor for many enzymatic reactions, including those involved in neurotransmitter metabolism. Individuals with pyridoxine-dependent seizures (PDS) need an unusually large daily intake of the PLP precursor pyridoxine to prevent fits, however, while it is known that PDS maps to 5q31, the mechanism of pyridoxine dependency in PDS is identified.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
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