Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants

Article Abstract:

New polyvalent vaccine antigens comprised of sets of mosaic proteins are designed, which are assembled from fragments of natural sequences and maximize the coverage of potential T-cell epitopes for HIV-1 variants. The mosaic proteins have provided diversity coverage comparable to that afforded by thousands of separate peptides, but they are tractable for vaccines because the fragments of natural proteins are compressed into a small number of native-like proteins.

T cells, Protein research, Antigenic determinants

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CD8.sup.} T-cell responses to different HIV proteins have discordant associations with viral load

Article Abstract:

The dominant [CD8.sup.} T-cell responses are analyzed in untreated HIV-infected individuals from KwaZulu-Natal, South Africa, in order to define the relationship between the specificity of the cellular immune response and viral control for a relevant human pathogen. Population based data has described the existence of both effective immune responses and responses lacking demonstratable biological impact in chronic HIV infection.

Usage, Prevention, HIV infection, HIV infections, AIDS vaccines, Cellular immunity

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Gradual adaptation of HIV to human host populations: good or bad news?

Article Abstract:

This article discusses the evolution and adaptation of HIV to its human host in terms of immunogenicity and pathogenicity, which impact its fitness and diversity. The implications of viral and host coevolution in HIV survival are presented.

United States, Analysis, Physiological aspects, HIV (Viruses), HIV, Genetic aspects, Adaptation (Physiology), Physiological adaptation, Host-virus relationships, Immunogenetics, Coevolution

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