Predominant T-H2-like bronchoalveolar T-lymphocyte population in atopic asthma

Article Abstract:

Analysis of fluid obtained from the lungs of asthma patients showed that T lymphocytes in their lungs were producing chemicals associated with immediate hypersensitivity. Bronchoalveolar lavage was used to retrieve lung cells from 15 asthma patients and 10 healthy individuals (the controls). The cells were tested for the presence of interleukin-2, interleukin-3, interleukin-4, interleukin-5, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon gamma. The asthma patients had significantly higher levels of the interleukins and GM-CSF in their lungs compared with the controls. Levels of interferon gamma in the lungs of asthma patients were similar to those in the controls. This indicates that asthma involves a subset of T lymphocytes - called T-H2 - that are involved in immediate hypersensitivity.

Measurement, Interleukins, T cells, Granulocyte-macrophage colony stimulating factor

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Clonality in nodular lymphocyte-predominant Hodgkin's disease

Article Abstract:

Many of the cells in nodular lymphocyte-predominant Hodgkin's disease are descended from a single B cell. Researchers analyzed part of the gene for the immunoglobulin heavy chain in tumor samples from five patients with this form of Hodgkin's disease. They analyzed a type of cell called lymphocytic and histiocytic (L&H) cells as well as other cells in the tumor. In all five patients, the gene was similar in the L&H cells, as well as other cells from the tumor and even other lymph nodes in the patient. This indicates that they all arose from a single B cell, a process called clonality.

Hodgkin's disease, Genetic aspects, Cancer cells

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Asthma

Article Abstract:

The immunology of asthma is discussed, focusing on the inflammatory action of IgE antibodies in the lungs. This research can lead to more effective treatments, such as those that block excess IgE production.

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