Pregnancy rates with fresh versus computer-controlled cryopreserved semen for artificial insemination by donor in a private practice setting

Article Abstract:

Artificial insemination by donor (AID) is a procedure used to achieve pregnancy with a donor's fresh or frozen sperm. The American Fertility Society recommends that AID recipients use frozen sperm, which is quarantined for six months, to decrease the chances of contracting a sexually transmitted disease. The abrupt switch from the previously preferred fresh semen to frozen semen did not allow time to compare pregnancy rates with the two methods. Frozen sperm inseminations are carefully timed to match ovulation in the woman, which is predicted by the blood level of luteinizing hormone. The pregnancy rates after AID were compared for fresh semen utilized exclusively from 1970 to 1988 versus frozen semen used from 1988 to the present. Included in the study were 580 women who underwent a total of 3,405 insemination cycles with fresh semen and 113 women who underwent 371 insemination cycles with frozen semen. The unadjusted pregnancy rate after AID with fresh semen was 48.5 percent and the cumulative pregnancy rate after seven insemination cycles was 59.6 percent. The unadjusted pregnancy rate after AID with frozen semen was 18.3 percent and the cumulative pregnancy rate after seven insemination cycles was 48.6 percent. Since there were fewer insemination cycles in the AID group using frozen semen, that may help explain why the overall unadjusted pregnancy rate was lower when frozen semen was used. Also, the fertility rate per insemination cycle was lower when frozen semen was used (5.9 percent versus 11.9 percent), but the overall probability of becoming pregnant was the same; this means that it may take longer to achieve a pregnancy when frozen semen is used. Semen donors who have higher sperm counts may improve the fertility rate per cycle. (Consumer Summary produced by Reliance Medical Information, Inc.)

Methods, Protection and preservation, Semen

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Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility

Article Abstract:

Infertile women who become pregnant with donor sperm may be at increased risk for developing preeclampsia compared to those impregnated with their partner's sperm. Preeclampsia rates were compared among 37 women artificially impregnated with donor sperm and 44 with their partner's sperm. None of the women had had any previous pregnancies. Preeclampsia developed in nine of the women impregnated with donor sperm and three of the women impregnated with their partner's sperm.

Health aspects, Care and treatment, Risk factors, Preeclampsia, Infertility, Female, Female infertility

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Pregnancy rates after transfer of cryopreserved blastocysts cultured in a sequential media

Article Abstract:

The study was undertaken to determine the pregnancy rate after transfer of cryopreserved blastocysts. It is concluded that cryopreservation and transfer of blastocysts appears to be a reliable procedure, and that the human blastocyst can be cryopreserved and thawed without a significant loss of viabilility.

United States, Science & research, Research, Embryo transplantation, Blastocyst

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