Altered viral fitness of HIV-1 following failure of protease inhibitor-based therapy

Article Abstract:

Protease inhibitors may inhibit viral reproduction even if they don't reduce viral levels substantially. This may explain why some HIV patients who take protease inhibitors experience an increase in CD4+ T cell counts even though viral levels don't decrease.

Research, HIV infection, Drug therapy, HIV infections, HIV (Viruses), HIV, Protease inhibitors, Virus replication, Anti-HIV agents

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Genotypic drug resistance and cause of death in HIV-infected persons who died in 1999

Article Abstract:

Death in most HIV patients is not caused by viral drug resistance, according to a study of 29 HIV patients. More often, death is caused by end-organ failure, incomplete immune restoration, or inability to suppress viral reproduction.

Health aspects, Patient outcomes, Mortality, HIV patients, Drug resistance in microorganisms, Microbial drug resistance

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Presence of mutation conferring resistance to lamivudine in plasma and cerebrospinal fluid of HIV-1 infected patients

Article Abstract:

The authors compared samples of cerebrospinal fluid (CSF) and plasma in which levels of HIV virus had been measured with samples from patients treated with lamivudine. They found a mutation which resists lamivudine in both CSF and plasma, which indicates that CSF and plasma HIV levels are related.

Analysis, Physiological aspects, Lamivudine, Blood plasma, Cerebrospinal fluid

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