Estrogen replacement therapy and fractures in older women
Article Abstract:
Estrogen replacement therapy appears to reduce the risk of bone fractures among elderly white women. A total of 9,704 nonblack women aged 65 or older were interviewed and their medical records reviewed. The women were also contacted every four months and asked if they had fallen or sustained a fracture. Women who had begun taking estrogen within five years of menopause and were taking estrogen at the time of the study had the lowest risk of fracture. However, there was less of a protective effect among long-term users who began taking estrogen later than five years after menopause. Women taking estrogen at the time of the study had 0.66 times the risk for all nonspinal fractures and 0.39 times the risk for wrist fractures compared with women who never took estrogen. The relative risk of hip fracture for women taking estrogen at the time of the study was 0.60 when compared with women who never took estrogen. Similar protective effects were seen whether women took estrogen alone or in conjunction with progesterone.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Effects of thiazide diuretic therapy on bone mass, fractures, and falls
Article Abstract:
Use of thiazide diuretics among older women is associated with a modest increase in bone mass but does not appear to lower the overall risk of fracture. Some studies have suggested that thiazide diuretics may lower the risk of bone fracture by reducing the excretion of calcium in the urine. Of 9,704 women over age 65, 2,637 were taking thiazides. Bone mass was higher among women taking thiazides than among women who had never taken them. There was no indication that taking thiazides increased the risk of falls. In three years of follow up, there were 1,113 non-spinal fractures among the women. There was no significant difference in the risk of all fractures between women who took thiazides and those who did not, but women who took thiazides had a slightly lower risk of hip and wrist fractures. There was no difference in the incidence of vertebral deformities between women who took thiazides and those who did not.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Prevalence and determinants of estrogen replacement therapy in elderly women. Appendicular bone density and age predict hip fracture in women
- Abstracts: Hormone replacement therapy and lipoprotein changes during early menopause. part 2 Enhancing patient compliance with hormone replacement therapy at menopause
- Abstracts: Prevention of bacterial endocarditis: recommendations by the American Heart Association. part 3 Optical immunoassay test for group A beta-hemolytic streptococcal pharyngitis: an office-based, multicenter investigation
- Abstracts: Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
- Abstracts: Does obstetric ethics have any role in the obstetrician's response to the abortion controversy? part 2 Argument-based medical ethics: A formal for critically appraising the normative medical ethics literature