Preventing the nosocomial transmission of tuberculosis
Article Abstract:
An expanded tuberculosis infection control program appears to effectively prevent the in-hospital transmission of tuberculosis from infected patients to health care workers. Researchers compared tuberculosis exposure among health care workers before and after an expanded infection control program was implemented in March of 1992. An average of 4.4 patients per month with infectious tuberculosis were not placed in respiratory isolation before the program was initiated compared to an average of .6 patients per month after the program was in place. The total number of days per month that potentially infectious patients with tuberculosis were not isolated decreased once the expanded policy was in force. The tuberculin skin test conversion rate in health care workers decreased from 3.3% between January and June, 1992 to less than 1% between July and December, 1993.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Acceptance of isoniazid preventive therapy by health care workers after tuberculin skin test conversion
Article Abstract:
Health care workers (HCW) who are required to have a tuberculosis test periodically and are encouraged to undergo treatment if positive may be more likely to complete the treatment. Researchers followed 125 HCW who tested positive for tuberculosis exposure at Grady Memorial Hospital in Atlanta, where HCWs must be tested every six months or face dismissal. Ninety-eight percent of the HCWs saw a physician after their test and were encouraged to begin treatment with isoniazid to prevent active tuberculosis. According to pharmacy records, 105 HCWs began isoniazid treatment, but only 69 completed six months of treatment. Eighty-three percent of the physicians completed treatment compared to 59% of the employees. Eleven percent of those who began isoniazid treatment developed a reaction to the drug.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Hepatotoxicity Associated With Isoniazid Preventive Therapy: A 7-Year Survey From a Public Health Tuberculosis Clinic
Article Abstract:
The anti-tuberculosis drug isoniazid appears to be safe when used to prevent tuberculosis in people who are infected with the bacterium that causes it. Researchers analyzed the rate of liver toxicity in 11,141 patients who began taking isoniazid to prevent tuberculosis after they had a positive TB test. A positive TB test means you have been exposed to the bacterium that causes tuberculosis but do not necessarily have the disease. Only 11 patients experienced liver toxicity as a result of the drug. Older patients and women were most likely to develop liver toxicity.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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