Aplastic anemia: which treatment?

Article Abstract:

Most patients with aplastic anemia who have an HLA-matched donor should receive a bone marrow transplant. Immunosuppressive drugs can be used if a patient does not have a matched donor.

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Primary treatment of acquired aplastic anemia: outcomes with bone marrow transplantation and immunosuppressive therapy

Article Abstract:

Matched bone marrow transplants may be the treatment of choice for young patients with aplastic anemia. Survival statistics and treatment responses were compared for 395 patients with aplastic anemia treated with either a matched bone marrow transplant or drug therapy to suppress the immune system. Eighty-nine percent of the patients who received a bone marrow transplant and 44% of those treated with immunosuppressive drugs had a favorable response to treatment. Sixty-nine percent of the patients receiving a bone marrow transplant were alive at 15 years compared to 38% of those treated with immunosuppressive drugs.

Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation

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Autoimmunity and its treatment in aplastic anemia

Article Abstract:

Overall, research studies have shown that bone marrow transplants and immunosuppressive therapy are equally effective in treating patients with aplastic anemia. There are, however, tradeoffs with both options. There can be severe side effects with bone marrow transplants but immunosuppressive medication may not completely and effectively treat the condition. Most patients do not have the luxury of finding a compatible transplant and must rely on immunosuppressive medication. A recently published study finding transplants to be preferable included only one patient treated with cyclosporine, the currently favored drug.

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