Initial plasma HIV-1 RNA levels and progression to AIDS in women and men

Article Abstract:

HIV-infected women may have lower viral levels than men but they may be just as sick, according to a study of 156 male and 46 female HIV patients. For this reason, doctors should not use viral levels alone to determine whether an HIV-infected woman should begin drug treatment.

Women, Physiological aspects, HIV infection in women

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Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS

Article Abstract:

A difference in the amino acid sequence of HLA-B*35 can affect an HIV patient's progression to AIDS. In some cases, a single amino acid change can affect this protein that is involved in the immune system response to infections.

HLA histocompatibility antigens, HLA antigens, Genetic polymorphisms

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Prognostic indicators for AIDS and infectious disease death in HIV-infected injection drug users: plasma viral load and CD4+ cell count

Article Abstract:

Levels of HIV virus and CD4+ cells in the blood can be used to predict the progression to AIDS and death from infection in injection drug users (IDUs) with HIV infection. CD4+ cells are white blood cells that fight infection, and a higher level is indicative of better immune system function. Researchers studied 522 male and female IDUs, mostly black, for up to eight years. Patients with the highest viral load and lowest CD4+ count had the highest probability of developing AIDS symptoms and death from infectious diseases. Viral load was more predictive, but both tests were useful in HIV prognosis.

Measurement, Prognosis, HIV infection, HIV (Viruses), HIV, Drug addicts, Drug abusers, Viremia, CD4 lymphocytes, Viral load

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