Progression of gastritis to monoclonal B-cell lymphoma with resolution and recurrence following eradication of Helicobacter pylori
Article Abstract:
Patients with a proliferation of lymph tissue in their stomachs should be treated with drugs to eradicate the bacterium Helicobacter pylori if it is present. A 61-year-old man being evaluated for anemia was found to have lymph aggregates in his stomach. Normally, lymph tissue is only found in the intestines. A repeat biopsy a year later showed more extensive lymph infiltration and 12 months later a biopsy revealed a monoclonal B cell lymphoma. Helicobacter pylori was also detected at this time. The man was treated with drugs to eradicate the bacterium and six months later the bacterium, the lymph infiltration and the B-cell lymphoma were undetectable. However, a year later the lymph infiltration and B-cell lymphoma had returned despite the absence of the bacterium. Researchers have found that the B-cell lymphoma may be caused by T cells directed against the bacterium, rather than the organism itself.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Helicobacter pylori infection and gastric cancer--for want of more outcomes
Article Abstract:
More research is needed to determine whether testing and treating people with Helicobacter pylori infection in the stomach will prevent the development of stomach cancer. A study published in 2004 showed that it might not be cost-effective to do so. Stomach cancer is the second most common cause of cancer death.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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