Neurophysiologic and immunologic abnormalities associated with feline immunodeficiency virus molecular clone FIV-PPR DNA inoculation
Article Abstract:
Feline immunodeficiency virus (FIV) proviral DNA can be used to study FIV infection in cats. FIV is related to HIV and causes a disease in cats similar to AIDS. Cats infected with FIV could be used as a model to study HIV infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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Prophylactic ZDV therapy prevents early viremia and lymphocyte decline but not primary infection in feline immunodeficiency virus-inoculated cats
Article Abstract:
Preventative treatment with the drug zidovudine in cats injected with feline immunodeficiency virus (FIV) does not inhibit FIV infection but does appear to delay progression of the disease. FIV is similar to human immunodeficiency virus (HIV), and FIV disease progression parallels that of HIV disease. Previous studies with ZDV had indicated it might prevent viral infection if taken before or soon after exposure to the virus. Of 17 cats studied, six were treated with ZDV and then injected with FIV, six were injected with FIV and five were controls. All 12 cats injected with FIV eventually tested positive for FIV-infection. However, levels of CD4 and CD8 cells, which are white blood cells that play a critical role in the body's immune system, were highest in cats treated with ZDV. Furthermore, two weeks after injection with FIV, transient antigenemia, a condition which indicates dissemination of the virus through the body, was seen in all six of the untreated cats but in none of the cats treated with ZDV.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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Frontal lobe neuronal injury correlates to altered function in FIV-infected cats
Article Abstract:
HIV and related viruses can damage the brain even if blood viral levels are not particularly high. This was demonstrated in a study of cats infected with feline immunodeficiency virus (FIV).
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
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