Histologic and biochemical study of the brain, heart, kidney, and liver in asphyxia caused by occlusion of the umbilical cord in near-term fetal lambs
Article Abstract:
Asphyxia appears to damage the heart, kidneys and liver in addition to the brain. This was the conclusion of a study on lambs. In the liver, the damage appears to be caused by oxidative stress.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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Brain lipid peroxidation and antioxidant levels in fetal lambs 72 hours after asphyxia by partial umbilical cord occlusion
Article Abstract:
Oxidative stress may cause brain damage in fetuses deprived of oxygen. Researchers measured physiologic indicators of free radical activity in the brains of six fetal lambs subjected to umbilical cord compression and six in which normal umbilical blood flow was maintained. Thiobarbituric acid reactive substance levels were elevated in the frontal and parietal white matter, basal ganglia, and thalamus brain regions. Concentrations of superoxide dismutase, an protective antioxidant, were also elevated in these brain regions. Asphyxiation may induce free radical damage to nerve cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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Physiologic and histologic changes in near-term fetal lambs exposed to asphyxia by partial umbilical cord occlusion
Article Abstract:
Asphyxia appears to produce different kinds of damage in the fetal brain. Asphyxia occurs when the fetus does not receive enough oxygen. Researchers caused asphyxia in fetal lambs by blocking the umbilical cord for about one hour. Three days later the lambs were killed and their brains were examined. Asphyxia produced a wide variety of changes, ranging from severe damage to mild damage. Even lambs that recovered from the asphyxia had brain damage.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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