Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers
Article Abstract:
A 28-day course of treatment with azithromycin may be effective in treating patients with malaria. Doctors gave azithromycin to two groups of 10 healthy volunteers two weeks before infection with malaria followed by either 7 days (group 1) or 28 days (group 2) of continued azithromycin treatment. They infected two additional healthy volunteers in each group and gave no azithromycin treatment (controls). None of the volunteers in group 2 developed malaria while only 40% of the volunteers in group 1 did not develop malaria. All of the controls developed malaria. The malaria symptoms and side effects from the azithromycin treatment were mild. All of the volunteers who developed malaria received treatment with chloroquine.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Inefficacy of allopurinol as monotherapy for Colombian cutaneous leishmaniasis: a randomized, controlled trial
Article Abstract:
Treatment with allopurinol alone for patients with a parasitic skin ulcer condition called leishmaniasis does not appear to be effective. Patterns of skin regrowth and incidence of recurrence were evaluated at 1.5 months and 12 months, respectively, for 157 patients with leishmaniasis treated with either allopurinol tablets, Glucantime injections, or placebo tablets. Of the patients with healed lesions, 93% were treated with Glucantime, 37% with placebo, and 33% with allopurinol. Two patients treated with allopurinol and one treated with placebo had recurring lesions 12 months after treatment.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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Primaquine prophylaxis against malaria in nonimmune Colombian soldiers: efficacy and toxicity
Article Abstract:
The drug primaquine appears to be effective in preventing malaria. Researchers randomly assigned 176 Columbian soldiers to take primaquine every day during 15 weeks of patrol duty or a placebo. Overall, 89% of the primaquine group was protected against any type of malaria. For specific types of malaria, effectiveness was 94% for falciparum malaria and 85% for vivax malaria. Three soldiers had severe side effects and six had mild to moderate side effects. The drug can be discontinued one week after leaving endemic areas.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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