Prostaglandin protects against bile salt induced increases in proton permeation of duodenal brush border membrane
Article Abstract:
In peptic ulcer disease (a condition in which the lining of the digestive tract is damaged by stomach acid), defective production of prostaglandins by the cells of the small intestine may occur. These compounds exert a variety of biological effects, including protection of cells in the digestive tract and the liver against damage caused by insufficient oxygen, alcohol, indomethacin (a nonsteroidal anti-inflammatory drug), and taurocholate (a bile salt). The mechanism by which this protective action is effected remains unknown, nor is it understood whether it results from direct effects on the cells or as a result of helping maintain blood flow to the region. To further investigate how prostaglandin protects the gastrointestinal tract from damage induced by bile salts (contained in bile, which enters the digestive tract to aid in digestion of fats), experiments were carried out using intestinal membranes from rabbits. A model system was developed to test the effects of high concentrations of bile salts on cells that line the intestine (brush border membrane cells). Of particular interest were changes in cell permeability (extent to which cells allow substances to pass through them) to protons (acid) when concentrations of bile salts were high, and whether prostaglandins could affect that permeability. Increasing the concentration of bile salts (deoxycholate, glycodeoxycholate or taurodeoxycholate) resulted in a significant increase in proton permeability of the brush border membrane cells. When cells were first bathed in a prostaglandin, however, the increase in proton permeability was much less. The results indicate that prostaglandins have a direct protective effects on cells of the intestine, and suggest that changes in cell membrane permeability to acid may be one mechanism by which this protection occurs. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Gut
Subject: Health
ISSN: 0017-5749
Year: 1991
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Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors
Article Abstract:
Microscopic examination of two tumors of the parenchymal (functional) parts of the kidney was consistent with the diagnosis of renal oncocytoma, a granular tumor of the kidney. Both tumors were found to have a combination of normal and abnormal genetic material (chromosomes). There were no other recurring abnormalities or rearrangements of chromosomes. Further analysis revealed a particular chromosome pattern occurring only in oncocytomas. These findings may be useful for diagnosing renal oncocytomas.
Publication Name: American Journal of Pathology
Subject: Health
ISSN: 0002-9440
Year: 1989
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