Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo
Article Abstract:
Transforming growth factor beta (TGF-beta) may protect against the destruction of joint cartilage induced by interleukin 1 (IL-1). IL-1 is a substance that reduces proteoglycan synthesis by cartilage cells and induces cartilage degradation. A study examined the effect of TGF-beta on cartilage destruction induced by IL-1. TGF-beta interfered with proteoglycan destruction induced by IL-1 both in serum free medium alone and in the presence of insulin-like growth factor 1. TGF-beta also increased proteoglycan synthesis in normal cartilage cells and cartilage cells whose proteoglycan synthesis had been suppressed by IL-2. Proteoglycan is a substance found in the extracellular matrix of connective tissue. IL-1 may play an important role in the development and progression of arthritis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
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Changes in cartilage proteoglycan aggrecan after intra-articular injection of interleukin-1 in rabbits: studies of synovial fluid and articular cartilage
Article Abstract:
Changes in aggrecan levels in joint fluid appear to reflect the cartilage changes that take place in response to inflammation. Aggrecan is a component of joint cartilage. Knee joint fluid and cartilage from rabbits were examined for the aggrecan by-products glycosaminoglycan (GAG), aggrecan chondroitin sulphate epitope 846, and keratin sulphate, after stimulating an inflammation response with human interleukin-1 alpha (IL-1a) or placebo. Decreases in GAG levels in stimulated cartilage corresponded with increased GAG levels in joint fluid. Changes were most notable in the middle joint compartment.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Hyaluronan production in human rheumatoid fibroblastic synovial lining cells is increased by interleukin 1beta but inhibited by transforming growth factor beta1
Article Abstract:
The production of hyaluronan appears to be regulated by various chemicals produced by the immune system. Hyaluronan is a compound in the synovial fluid inside joints. Researchers used cell culture containing synovial cells to study the effect of various immune system chemicals on hyaluronan production. Interleukin 1beta stimulated hyaluronan production but transforming growth factor beta1 inhibited it.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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