Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor
Article Abstract:
Oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Urgently needed: a filter for the HIV-1 vaccine pipeline
Article Abstract:
As a part of prophylactic vaccine to counter the spread of HIV-1, researchers are trying to make immunogens, which are intended to elicit the neutralizing antibody responses. The need for assay standardization and creation of a centralized testing facility that could distribute consensus protocols and reagents is discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120
Article Abstract:
Research demonstrates that vaginal administration of the human monclonal antibody b12, produced against HIV-1 gp120 protein, protects macaque monkeys from simian-human immunodeficiency virus infection through the vagina. Data indicate that this protection is dose dependent with low doses being less effective.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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