Quality of HMO vaccination databases used to monitor childhood vaccine safety

Article Abstract:

The quality of automated vaccination databases has been evaluated by comparing the databases with paper-based medical records at three large West Coast health maintenance organizations (HMOs) that participate in the Vaccine Safety DataLink study. Separate analyses were conducted for each HMO and for each vaccine type given 1991-95. Agreement of automated and abstracted vaccinations was based on identical triads of child identical triads taking in date of vaccination, vaccine type and identification number. Lack of automated data was the kind of discrepancy that turned up most frequently. In second place were data mismatches and then vaccine type mismatches. Vaccination exposure classification errors in the range reported were found by mathematical modeling to bias modestly the measured medical outcome rate ratios toward the null hypothesis. Results support usefulness of vaccination exposure data derived from the automated HMO vaccination databases.

United States, Management, Quality management, Vaccines, Records and correspondence, Health maintenance organizations, Immunization of children, Immunization, Database administration, Information systems, Automated documentation

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Incidence of congenital rubella syndrome and influence of the rubella vaccination program for schoolgirls in Japan, 1981 - 1989

Article Abstract:

A nationwide survey of deaf children was conducted in 1984 in Japan that showed the incidence of congenital rubella syndrome was similar to the US and Europe. A second survey in 1993 evaluated the effectiveness of the vaccination program introduced in Japan in 1977. During the 1987 and 1988 epidemic, incidence rates between eligible and non-eligible mothers for vaccination was significant, suggesting a need to introduce a vaccination program to suppress another rubella epidemic.

Japan, Prevention, Social policy, Genetic aspects, Vaccination of children, Vaccination, Rubella, Deafness

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Nausea during pregnancy and congenital heart defects: a population-based case-control study

Article Abstract:

Severe morning sickness during pregnancy may be associated with a lower risk of congenital heart defect for the baby. Women with severe nausea, some of whom used the antinausea medication Bendectin, had the lowest risk of having a baby with a congenital heart defect. This link did not exist among women with less severe forms of nausea and those who never used Bendectin. Pregnancy hormones or ingredients in Bendectin may be crucial for normal heart development.

Health aspects, Risk factors, Congenital heart defects, Congenital heart disease in children, Morning sickness (during pregnancy), Morning sickness, Bendectin (Medication)

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