Remitting seronegative symmetrical synovitis with pitting oedema: disease or syndrome?
Article Abstract:
Evidence suggests that remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a syndrome rather than a disease. RS3PE is a condition characterized by symmetrical joint inflammation and tissue damage caused by fluid buildup that usually does not recur. Researchers reviewed the records of 24 patients diagnosed with RS3PE over a 20 year period. All of the patients developed symptoms quickly and later in life (60-86 years of age), had arthritis in more than one location, and had fluid buildup producing tissue erosion in either the hands or feet. All of the patients initially responded favorably to anti-inflammatory or anti-malarial drugs. However, eleven patients developed other rheumatic diseases 18 months to 12 years after the initial diagnosis of RS3PE. This indicates that these 11 patients may not have had RS3PE at all but rather the initial symptoms of the underlying rheumatic diseases.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Tendon lesions and soft tissue rheumatism - great outback or great opportunity?
Article Abstract:
Several approaches to the study of tendon diseases such as rheumatism show promise in better understanding the origin and progression of this disease. Researchers highlighted results from four different approaches and proposed a theory to explain the course of tendon disease. The damage and repair processes may involve a cycle of injury, a change in cell structure, formation of a cartilage and fiber substance, followed by either tendon repair or further deterioration and rupture. Tissue sample studies of damaged tendons have shown that injured fiber cells may be a different size, arranged differently, may have died, or may contain calcium deposits. Studies of the damaged cells indicate that these cells can function and repair themselves. Chemical tests of these damaged cells show evidence of the repair process.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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