Heterogeneity of T cell lymphoblastic leukaemias

Article Abstract:

Fifteen to 25 percent of acute lymphoblastic leukemias (ALL) originate from T lymphocytes. Twenty-eight cases of T cell acute lymphoblastic leukemias (T ALL) were examined in which cells from the patients were classified using various biochemical techniques. Considerable heterogeneity among the cells were found and different stages of T cell development were represented. Twenty-eight percent of the leukemias originated from pre-T cells (cells that had not matured into T cells by passing through the thymus gland); 36 percent were derived from immature thymus cells; 24 percent had features of cortical thymocytes (cells located in a certain area of the thymus), and 12 percent were from mature T cells. The leukemias from pre-T cells had different biological features than the leukemias from T cells. The pre-T cell leukemias originated from cells in the bone marrow rather than the thymus, as in cases of T ALL. Comparison of the clinical features of the two types of leukemias showed that the pre-T leukemias more closely resembled cases of ALL that were not of T cell origin. It is concluded that T ALL are a heterogenous group of leukemias that originate from different sites in the body. No differences were seen in response to treatment, including remission or survival rate, among the different types of ALL. (Consumer Summary produced by Reliance Medical Information, Inc.)

Development and progression, Lymphocytic leukemia

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Long-term results after operative correction of vaginal aplasia

Article Abstract:

Surgical construction of an artificial vagina appears to significantly improve sexual function, confidence, and satisfaction in women with an abnormal vagina. Artificial vaginas were surgically constructed in 44 women with either Mayer-Rokitansky-Kuster syndrome, a vaginal birth defect, or vaginal loss from cancer treatment. New vaginal length varied from 3.5 centimeters (cm) to 15 cm. Women with vaginas longer than 6 cm had no problems with sexual intercourse. Eighty-two percent of the women reported significant improvement in sexual function and confidence.

Surgery, Birth defects, Surgery, Plastic, Plastic surgery, Vagina

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