Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression
Article Abstract:
Patients who have a return of their depressive symptoms after treatment may have abnormal brain function in the orbitofrontal cortex, the dorsolateral prefrontal cortex, and the thalamus. This was the conclusion of researchers who used PET imaging to measure the metabolic activity in the brains of 18 patients who were successfully treated for depression. They were given a substance that reduces the amount of several neurotransmitters involved in depression.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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Research on major depression: strategies and priorities
Article Abstract:
Priorities for research on depression include identifying susceptibility genes and other risk factors, determining what goes on in the brain during depression, developing new treatments, reducing the suicide rate, decreasing the impact of depression on physical diseases, and educating doctors to provide more effective treatments to patients with depression. Depression is a common, chronic illness that causes much suffering and disability.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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Treatment of depression in patients with alcohol or other drug dependence: a meta-analysis
Article Abstract:
A systematic review and meta-analysis, to quantify the efficacy of antidepressant medications for treatment of combined depression, and substance use disorders is conducted. The result of the study concluded that antidepressant medication, exerts a modest beneficial effect for patients with combined depressive-and substance-use disorders.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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