The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis

Article Abstract:

Balloon angioplasty is no more effective than antihypertensive drugs in treating patients with hypertension and renal artery stenosis. Stenosis is the medical term for any condition that blocks an artery. In this case, it's the renal artery, which supplies blood to the kidneys. Balloon angioplasty is used to remove the blockage. However, in a study of 106 patients with hypertension and renal artery stenosis who were randomly assigned to drug therapy or balloon angioplasty, outcomes were similar in both groups.

Antihypertensive drugs, Antihypertensive agents

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Renal angioplasty for lowering blood pressure

Article Abstract:

Not all patients with hypertension and renal artery stenosis will benefit from angioplasty. Stenosis is the medical term for any condition that blocks arteries. Renal artery stenosis affects the artery that supplies blood to the kidneys. A study published in 2000 found that angiioplasty, which opens blocked arteries, was no more effective than antihypertensive drugs in treating patients with hypertension and renal artery stenosis. However certain patients may still benefit from angioplasty.

Editorial

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Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents

Article Abstract:

The kidney regulates blood pressure by several mechanisms, including the renin-angiotensin-aldosterone system, which affects vasoconstriction (constriction of blood vessels), sodium excretion, and other factors. To learn more about the role of the kidney in the development of high blood pressure (hypertension), a study was performed with young people (aged 7 to 32) who were at high or low risk of developing hypertension based on their family histories. Research has shown that a person's risk of developing hypertension is related to the blood pressure of his parents: those with hypertensive parents are at greater risk than those with parents who are normotensive (have normal blood pressure). Several aspects of kidney (renal) function were measured in the subjects, who did not yet have hypertension. The goal was to study early, subtle factors that might be involved in the genesis of the disorder. A variety of tests were carried out on 41 subjects with two normotensive parents; 52 subjects with one normotensive and one hypertensive parent; and 61 subjects with two hypertensive parents. Results showed that the subjects in the latter group had higher systolic and diastolic blood pressures (the top and bottom number of a blood pressure reading) than those in the other two groups. Test results are presented for a variety of measurements, including renal blood flow, glomerular filtration rate (the rate at which the kidney filters fluid from the blood), blood levels of renin, aldosterone, and angiotensin, and other factors. In summary, subjects with hypertensive parents had lower renal blood flow, lower renin activity in the blood, and lower blood levels of renin and aldosterone than those with normotensive parents. Test values of the subjects with one normotensive and one hypertensive parent usually fell in between the other two groups. Although the mechanisms responsible for these differences have not been identified, the results show that changes in kidney hemodynamics in the direction of hypertension occur early in life in people at risk for the disorder. (Consumer Summary produced by Reliance Medical Information, Inc.)

Risk factors, Physiological aspects, Development and progression, Kidneys, Kidney, Renin-angiotensin system

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