Annexin II and bleeding in acute promyelocytic leukemia

Article Abstract:

Annexin may be responsible for the increased bleeding tendency in patients with acute promyelocytic leukemia (APL). Annexin is a receptor on the surface of some cells that binds proteins involved in blood clotting. Researchers compared the expression of annexin in leukemic cells from 14 patients with APL or some other type of leukemia. The expression of annexin was higher in the cells of patients with APL than in the cells of other leukemia patients. These cells were more likely to produce an enzyme called plasmin, which dissolves blood clots and increases the risk of bleeding.

Causes of, Physiological aspects, Acute leukemia, Promyelocytic, Acute myelocytic leukemia, Bleeding

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Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype

Article Abstract:

Bone marrow transplantation may be more successful if T cells are removed from the marrow before transplantation. If the donor and recipient are not completely compatible, these T cells can attack the recipient, causing graft-versus-host disease. Researchers used a technique to remove T cells from bone marrow samples before the marrow was transplanted into 43 patients with leukemia. Although 40% died from complications of transplantation, none developed graft-versus-host disease. Most of the surviving patients were free of disease.

Health aspects, Care and treatment, Hematopoietic stem cells, Hematopoietic stem cell transplantation, Histocompatibility, Acute leukemia

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