Right ventricular function in chronically anemic fetal lambs

Article Abstract:

Fetuses with chronic anemia may experience fluid buildup in tissues even though the heart adapts to the anemia. Researchers induced increasingly severe anemia in five lamb fetuses to analyze whether heart failure causes fluid buildup in tissues. Pressure in the right atrium of the heart remained normal even though the stroke volume of the right heart ventricle and heart blood flow increased. The sensitivity of the right ventricle to elevated pressure remained normal, suggesting that ventricular wall thickness and stress and ventricular radius did not change. These findings indicate that the fetal heart adapted to the stress of chronic anemia. Fluid buildup in chest and abdominal tissues still occurred, however. Heart adaptation to extreme anemia may be limited.

Abnormalities, Anemia, Complications and side effects, Fetus, Pregnancy, Fetal heart, Anemia in pregnancy, Prenatal ultrasonography

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Effects of estrogen and progestin on aortic size and compliance in postmenopausal women

Article Abstract:

Estrogen therapy may produce stronger cardiovascular benefits in postmenopausal women than estrogen therapy combined with progestin. Researchers assigned 26 postmenopausal women to either estrogen therapy or to a combination of estrogen and progestin. Women receiving estrogen only experienced a significant increase in the size of the ascending and descending aorta, as measured by magnetic resonance imaging, after three months of treatment. Aortic size did not change in women taking the estrogen-progestin treatment. Estrogen may also make the aorta more responsive to changes in blood pressure, another cardiovascular benefit.

Health aspects, Cardiovascular diseases, Prevention, Hormone therapy, Postmenopausal women, Progestational hormones, Aorta

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The sequential effects of estrogen administration and hypertension on cardiac function in ewes

Article Abstract:

Estrogen and hypertension appear to have opposite effects on the heart. Researchers used female sheep who were either given estrogen or made hypertensive by obstructing the aorta. After three weeks, the sheep were given the opposite treatment. Estrogen caused the heart to increase in size and heart function dropped when these sheep were then made hypertensive. However, the sheep who were made hypertensive first had no heart changes even when they received estrogen.

Hypertension, Heart

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