Postmortem molecular analysis of scn5a defects in sudden infant death syndrome

Article Abstract:

A mutation in the sodium channel gene called scn5a may be the cause of some cases of sudden infant death syndrome (SIDS). This mutation can cause a heart arrhythmia, even in healthy adults. In a study of 93 tissue samples taken from babies who died of SIDS, two had the mutation.

Sudden infant death syndrome

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Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome

Article Abstract:

A study of 2772 participants was conducted to identify risk factors associated with aborted cardiac arrest and sudden cardiac death during adolescence in patients with clinically suspected long-QT syndrome (LQTS). Findings indicate that the timing and frequency of syncope, the degree of QTc prolongation and sex are independent predictors of life-threatening events in adolescents with LQTS.

United States, Youth, Patient outcomes, Teenagers, Cardiac arrest, Long QT syndrome, Clinical report

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Molecular diagnosis of the inherited long-QT syndrome in a wome who died after near-drowning

Article Abstract:

A woman who died after a near-drowning incident was found to have the long-QT syndrome. This is a heart arrhythmia that is often caused by a gene mutation affecting channels in heart muscle that transport ions. After exercising at a gym, she swam in the pool and was found face-down at the bottom several minutes later. She was resuscitated, but remained comatose and eventually died. Before her death, she was noted to have long-QT syndrome, and molecular analysis of her heart muscle revealed a gene mutation in the potassium channels. Some accidental drownings may be caused by long-QT syndrome.

Drowning

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