Risk of recurrence after myomectomy

Article Abstract:

Uterine myomas (fibroids; fiber-like tumors of the muscular layer of the uterus) are the most common pelvic tumors in women; they can cause infertility, distortion of the uterus, blockage of the fallopian tubes (through which the egg travels to the uterus), and changes in the arrangement of uterine blood vessels. Myomas are often surgically removed in a procedure called myomectomy, but regrowth of these tumors is common. To learn more about the incidence of fibroid recurrence after myomectomy, results were analyzed from a large number of patients (622) who underwent myomectomy over a 15-year period. Surgery was performed because of pelvic pain or menorrhagia (excessive bleeding at the time of menstruation; 59 percent), infertility (36 percent), or recurrent miscarriage (5 percent). After a median follow-up time of 8.5 years, myomas had recurred in 27 percent of the women; the recurrence rate increased with time. The frequency of recurrence did not differ by age at the time of diagnosis or by the location of the tumor within the uterus. Women with single tumors and those who gave birth to a child after their surgery had lower rates of recurrence than those with multiple tumors and those who did not subsequently bear children. Approximately 20 percent of the original group of women were lost to follow-up; this was a major drawback for interpreting the results. A discussion is presented of the medical literature concerning recurrence of myomas after myomectomy. (Consumer Summary produced by Reliance Medical Information, Inc.)

Surgery, Myometrium, Myomectomy, Uterine tumors

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Recurrence in affective disorder: analyses with frailty models

Article Abstract:

The risk of affective disorder's recurrence is highly influenced by the person's past episodes and tendency toward recurrence. In this research, newly developed frailty models were used for the estimation of the effect of the number of episodes on the occurrence rate. For women suffering from unipolar disorder and other patients with bipolar disorder, reoccurrence rate was affected by the number of past episodes. Researchers found no effect of episodes, but they found a large effect of the frailty parameter for unipolar men. Researchers concluded that the risk of recurrence increased with each episodes of bipolar affective in general and for women with unipolar disorder.

Research, Depression, Mental, Depression (Mood disorder), Affective disorders, Mood disorders, Bipolar disorder

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AIDS-related malignancies

Article Abstract:

This review describes the pathophysiology of Kaposi's sarcoma and non-Hodgkin's lymphoma and the effect of anti-HIV agents on these tumors. Research indicates that although HIV itself does not cause cancer, it facilitates creation of an immunologic background that enables cancer viruses to escapeimmune control leading to tumor formation.

United States, Causes of, Physiological aspects, HIV infection, HIV infections, Non-Hodgkin's lymphomas, Kaposi's sarcoma, Tumours

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