SOCS-3 regulates onset and maintenance of T sub H 2- mediated allergic responses
Article Abstract:
A strong correlation between suppressor of cytokine signaling (SOCS-3) expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients is provided. SOCS-3 transgenic mice showed increased T sub H 2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Escape of malaria parasites from host immunity requires CD4+CD25 regulatory T cells
Article Abstract:
Inflection with malaria parasites regularly induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Results recommend activation of T cells contributes to immune suppression during malaria infection and helps malaria parasites to escape from host immune responses.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Regulatory T cells and mechanisms of immune system control
Article Abstract:
The mechanisms used to control and regulate the immune system, to prevent or minimize reactivity to self-antigens or an overxuberant response to pathogen will result in damage to the host. Active suppression mediated by regulatory T (T(sub reg)) cell populations is used to avoid the damage to the host.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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