Breast cancer and other second neoplasms after childhood Hodgkin's disease

Article Abstract:

People who received radiation treatment for Hodgkin's disease during childhood may have an increased risk of second cancers, and, if they are women, this risk is particularly high for breast cancer. Researchers reviewed the medical records of 1,380 children diagnosed with Hodgkin's disease. During a median follow-up of 11.4 years, 88 cancers developed among this population, while the expected incidence in the general population was 4.4. This indicates that children treated for Hodgkin's had 18 times the risk of developing cancer later in life than the general population. The risk for breast cancer was 75 times higher in this group than in the general population. This risk of breast cancer increased with radiation dose and older age at treatment. The risk of leukemia was 79 times higher than in the general population and increased with older age at Hodgkin's diagnosis, late stage of Hodgkin's at diagnosis, treatment with alkylating agents, and Hodgkin's recurrence.

Complications and side effects, Hodgkin's disease, Pediatric diseases, Breast cancer, Cancer, Hodgkin's disease in children

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Chronic health conditions in adult survivors of childhood cancer

Article Abstract:

A study was conducted to investigate the large and geographically diverse cohort that is followed in the childhood Cancer Survivor Study (CCSS), with the goal of determining the prevalence, incidence, and severity of chronic health conditions in adult survivors of childhood cancer, and to determine the risk of chronic conditions in the survivors, as compared with their siblings. The findings suggest that survivors of childhood cancer have a high rate of illness owing to chronic health conditions.

Health aspects, Care and treatment, Diagnosis, Cancer in children, Childhood cancer, Cancer survivors, Disease/Disorder overview

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