Sequence of neuronal responses assessed by immunohistochemistry in the newborn rat brain after hypoxia-ischemia
Article Abstract:
Heat shock protein-72 (HSP-72) and microtubule-associated protein-2 (MAP-2) levels appear to reflect cell damage seen after oxygen deprivation in an area of the brain called the hippocampus. HSP-72 and MAP-2 levels were measured in the brains of seven-day-old rats killed at designated time points between one and 72 hours after the main blood vessel supplying oxygen to one half of the brain was tied off. Brain damage was examined microscopically after death. HSP-72 levels peaked and MAP-2 levels reached their lowest point 24 hours after injury. Most of the brain damage occurred in the CA3 region of the hippocampus.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Heat shock protein 70 and heat shock cognate protein 70 messenger ribonucleic acid induction in the brains, hearts, and livers of neonatal rats after hypoxic stress
Article Abstract:
The fetus may produce a protein called heat shock cognate protein 70 under stressful conditions to protect the heart and brain from damage. Researchers measured the amount of this protein in the heart, brain, and liver of seven-day-old rats who had been subjected to low levels of oxygen. This caused blood oxygen levels and brain temperature to drop. It also caused the level of heat shock cognate protein 70 to increase in brain and heart but not in liver.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Limited differentiation to neurons and astroglia from neural stem cells in the cortex and striatum ischemia/hypoxia in the neonatal rat brain
Article Abstract:
A study is conducted to examine whether progenitor neutral cells can differentiate successfully into mature neutrons and atrocities in a rat model of neonatal hypoxic-ischemic encephalopathy. The intrinsic ability for neurologic self-repair is limited at the maturation step after hypoxic-ischemic stress in the neonatal rat brain.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Fetal fibronectin and bacterial vaginosis are associated with preterm birth in women who are symptomatic for preterm labor
- Abstracts: There are lessons to be learnt in the aftermath of a scandal
- Abstracts: Recurrence of spontaneous versus medically indicated preterm birth. Racial disparity in fetal growth inhibition among singletons and multiples
- Abstracts: Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
- Abstracts: Cancer care quality assessed. Full-body CT scans scale up cancer risk. Cancer survivors need better care: New report makes recommendations