Sexually transmitted diseases in mothers of neonates with congenital cytomegalovirus infection

Article Abstract:

Cytomegalovirus (CMV) is the most common viral infection that is inherited at birth. It is estimated that one percent of all infants are infected with CMV when they are born. CMV infection damages vision, hearing, nerves and intellectual ability in 10 to 20 percent of the infants who become infected. To reduce the incidence (number of new cases) of CMV infection in newborns, methods of preventing CMV infection in women are needed. CMV is transmitted during sexual contact with an infected partner. This article describes the results of a study designed to identify risk factors associated with maternal CMV infection and passing the infection to an infant at birth. The study included 175 mothers who had babies with CMV infections. Most of the women (84 percent) were black and from low income families. Almost 90 percent of the women received prenatal care. Women who had other sexually transmitted diseases, such as gonorrhea and trichomoniasis (a type of vaginal infection), were two times more likely to give birth to a baby with CMV infection. Women who were poor, unmarried and young were four times more likely to give birth to a baby infected with CMV than women who were married, older and from higher income families. These results suggest that women who have sexually transmitted diseases, are young, unmarried and poor, have a greater risk of having a baby with CMV infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Sexually transmitted diseases, Complications and side effects, Risk factors, Infants (Newborn), Neonatal diseases

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The outcome of congenital cytomegalovirus infection in relation to maternal antibody status

Article Abstract:

Pregnant women who have had recurrent cytomegalovirus (CMV) infections produce antibodies that may protect their baby from developing CMV infection after birth. Congenital CMV infections can cause hearing loss, eye diseases, mental retardation and neurological damage. Of 197 infants with congenital CMV infections, 132 had mothers who were became infected during the pregnancy (primary infection), and 65 had mothers who had been infected before the pregnancy (recurrent infection). Eighteen percent of the infants whose mothers had a primary infection had symptoms of congenital CMV infection at birth compared to none of the infants whose mothers had recurrent infections. At approximately four-and-a-half years of age, 25% of the children in the primary infection group had a complication of CMV infection, but only eight percent of the children in the recurrent infection group were affected. Vaccinating all women of childbearing age against CMV could prevent 6,000 congenital CMV infections each year.

Physiological aspects, Infants

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Intrauterine transmission of cytomegalovirus to infants of women with preceonceptional immunity

Article Abstract:

Pregnant women who are immune to a particular type of cytomegalovirus can still transmit cytomegalovirus infection to their baby if they become infected with a different type. Babies who contract cytomegalovirus from their mothers at birth can develop brain damage and hearing loss.

Health aspects, Maternal-fetal exchange

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