Shared idiotypes expressed by human B-cell lymphomas

Article Abstract:

Immunoglobulins are antibodies produced by the body in response to foreign substances. Each area of the immunoglobulin has a unique binding site for these substances, or antigens. It has been found that these binding sites can themselves be perceived as antigens. These areas of the immunoglobulin, known as idiotypes, evoke the production of other antibodies, antiidiotypes. Cancer cells also produce these unique idiotypes and therapy using antiidiotypes to combat them has been suggested. Antiidiotypes were produced for 67 patients with a specific type of cancer, B- cell lymphoma. Different B-cell lymphomas have been found to have similar, or shared, idiotypes. The twenty antiidiotypes produced from the 67 patients were evaluated for binding ability to their own idiotypes. It was found that 33 percent of the B-cell lymphomas and 27 percent of the small-cleave-cell-lymphomas reacted. It is concluded that antibodies that react with shared idiotypes are more readily available and should be used instead of antiidiotypes made specifically for each patient to treat lymphomas.

Health aspects, Immunoglobulins, Immunoglobulin idiotypes

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Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors

Article Abstract:

A vaccine prepared from antibodies produced by cancer cells may be an effective treatment for patients with B-cell lymphoma. B-cell lymphoma is a form of cancer that affects B-cells, or cells of the immune system that produce antibodies. Among nine patients with B-cell lymphoma who were injected on several occasions with a vaccine prepared from antibodies produced by their own malignant B-cells, seven experienced an immunological response after the injections. Two patients who had measurable tumors experienced a complete regression of their tumor. Seven patients had been in remission, and all but one remained in remission an average of 10 months after treatment. None of the patients experienced any severe side effects.

Research, Vaccines, Tumor antigens

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Prediction of survival in diffuse large-B-cell lymphoma based on the expression

Article Abstract:

A study conducted on 36 genes, whose expressions had been reported to predict survival in diffuse large-B-cell lymphoma, is presented. According to the results, the measurement of six genes is sufficient to predict overall survival in diffuse large-B-cell lymphoma.

United States, Diagnosis, Gene expression

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