Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody
Article Abstract:
Molecular imaging of cancer using signal amplification of a radiotracer in situ by pretargeting a multivalent, bispecific antibody to carcinoembryonic antigen (CEA), which subsequently also captures a radioactive haptenpeptide is described. Human colon cancer xenografts as small as ~ 0.15g are disclosed in nude mice within 1 h of giving the radiotracer.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Getting to the guts of NOD2
Article Abstract:
Mutations in NOD2, encoding an intracellular bacteria-sensing protein are associated with Crohn disease. Two studies in mice investigate how these mutations may affect innate immunity to microbes in the intestine and progression of disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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