Silicone breast implants and the risk of connective-tissue diseases and symptoms

Article Abstract:

There may be no association between silicone breast implants and any type of connective tissue disease. Researchers followed 87,501 women in the Nurses' Health Study from June, 1976 to May, 1990. A total of 1,183 of the nurses had a breast implant and 876 had a silicone implant. During the 14-year follow-up, 516 women were diagnosed with some type of connective tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus or scleroderma. Three of these women had breast implants. The incidence of connective tissue disease was no higher in the women with breast implants than in those who did not have breast implants. A total of 904 women had signs or symptoms suggesting connective tissue disease, but no confirmed diagnosis. Six of these women had breast implants, and this incidence rate was no higher than the rate in women without breast implants.

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Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases

Article Abstract:

There appears to be no link between breast implants and connective tissue diseases. This was the conclusion of researchers who used several meta-analysis techniques to evaluate 20 studies of breast implants and connective tissue diseases. No association was found between breast implants and rheumatoid arthritis, systemic lupus erythematosus, scleroderma, systemic sclerosis, Sjogren's syndrome, or any other connective or autoimmune disease. This was true even for silicone-gel implants.

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Experience of a scientific panel formed to advise the federal judiciary on silicone breast implants

Article Abstract:

Scientific advisory panels can be used to provide courts with an unbiased assessment of the scientific literature on specific topics. In 1996, a federal judge appointed four scientists with experience in immunology, epidemiology, toxicology, and rheumatology to the National Science Panel to evaluate the evidence linking breast implants to connective tissue diseases. Three of the panel's members discuss the results and give their recommendations for future scientific panels.

Analysis, Evidence, Expert, Expert evidence

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