Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host
Article Abstract:
Infection of newborn African green monkeys with simian immunodeficiency virus does not appear to cause disease. Simian immunodeficiency virus of African green monkeys (SIVagm) does not cause disease in adult African green monkeys, but causes rapidly progressing AIDS-like disease in other primates. Researchers infected newborn African green monkeys with SIVagm, but none developed the infection. Newborn African green monkeys have more circulating CD4+ T-cells, the target of SIVagm infection, than adults. It is unclear how neonatal African green monkeys resist SIVagm infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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HERV-K: the biologically most active human endogenous retrovirus family
Article Abstract:
The biological function of human endogenous retroviruses (HERV) is still unknown. HERV are gene sequences in the human genome that are similar to exogenous retroviruses. The HERV-K family of viruses is the most well-known. They occur in humans and Old World monkeys and apes. They produce proteases and polymerases but no reverse transcriptase has yet been isolated. They produce viral proteins but no infectious particles have been found so far. HERV-K viruses may protect human against infection by closely related exogenous retroviruses by blocking cell receptor binding.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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The immunosuppresive peptide of HIV-1 inhibits T and B lymphocyte stimulation
Article Abstract:
A synthetic peptide similar to an immunosuppressive region on a HIV glycoprotein may inhibit T-cell and B-cell growth and promote the development of AIDS. The peptide resembles the immunosuppressive domain of gp41, the glycoprotein embedded in the envelope coat of the human immunodeficiency virus. Immunosuppressive peptide (ISU-peptide) of HIV-1 prevents T-cell growth by inhibiting mitogen and lymphokine stimulation of the cells. The ISU-peptide can inhibit proliferation in both mouse and human lymphocytes and can only react when connected to a carrier protein.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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