Staphylococcal enterotoxin B increases the severity of type II collagen induced arthritis in mice
Article Abstract:
Staphylococcal enterotoxin B (SEB) treatment may not halt or lower arthritic response to collagen type II (CII) in mice and may increase the severity of collagen type II arthritis in arthritic mice. In a study to examine the changes of V-beta-8 T cell subsets during the induction of arthritis by CII immunization, genetically identical mice were injected with SEB and then with CII to induce an arthritic response, with saline alone, and with CII only. Mice with arthritis induced from CII injection were treated therapeutically with SEB as well. Mouse tissue was analysed for V-beta-8 and V-beta-6 activity and expression of V-beta T cell receptors. Mice were also physically monitored for arthritic symptoms. Mice treated with initially with SEB, compared with CII-only controls, showed a decrease in V-beta-8 T cells only and no change in CII antibody response. Mice with CII immunization showed no T cell compliment differences. Therefore, mice treated with SEB before onset of arthritis achieved no benefit. Mice treated with SEB after onset of arthritis suffered a hastening of the illness and more serious symptoms.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice
Article Abstract:
Calpain may be one of the enzymes involved in degrading cartilage during the arthritic process. Calpain breaks down connective tissue, which forms part of the cartilage matrix. Arthritis was induced in mice by injecting bovine connective tissue protein. At various points after induction of arthritis, the animals were killed and the joint tissue examined microscopically. Slides were stained to identify calpain. Calpain was not found at all or only in small amounts before arthritis induction or in control animals. Calpain was found in abundance during the acute stage of arthritis throughout the various joint tissues. As the acute phase subsided, calpain could still be identified but in lesser amounts.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Influence of long term silicone implantation on type II collagen induced arthritis in mice
Article Abstract:
The authors investigated the claims that silicone implants may be involved in autoimmune connective tissue diseases. Their experimental model in mice showed production of connective tissue antigen autoantibodies and susceptibility to autoimmune disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: AstraZeneca announces discovery of a new class of antibiotic. 'Fast-track' drug approvals hit speed bumps in Japan
- Abstracts: Why is verbal abuse getting worse? The use of technology to help patients with self-medication. Being assertive in the workplace
- Abstracts: 16th Annual Meeting of the Society of Perinatal Obstetricians. Notable presentations in the history of the South Atlantic Association of Obstetricians and Gynecologists
- Abstracts: Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. CCR5 and CXCR4 expression on memory and naive T cells in HIV-1 infection and response to highly active antiretroviral therapy
- Abstracts: How to plot a course for safety training. Design your plant with ergonomics in mind. Is Europe prepared for a graying work force?