Prognostic factors of combined viral load and CD4+ cell count responses under triple antiretroviral therapy, Aquitaine Cohort, 1996-1998
Article Abstract:
Highly active antiretroviral therapy (HAART) may suppress the virus without increasing CD4+ T cell counts or increase CD4+ T cell counts without suppressing the virus. HIV RNA levels, age, pretreatment, and saquinavir therapy determined which type of response predominated.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Survival after AIDS-defining events in patients with fewer than 200 lymphocytes CD4+ x 10(super)6/L who are toxoplasmosis antibody positive
Article Abstract:
Certain opportunistic infections appear to increase the risk of death in some AIDS patients. Researchers followed 187 HIV-infected patients who tested positive for toxoplasmosis and had CD4 T cell levels below 200 but had no AIDS-defining event. A 10-year increase in age doubled the risk of death in these patients and a further decline in CD4 counts also increased the risk slightly. However, infection with Pneumocystis, cytomegalovirus or toxoplasmosis all increased the risk of death 10-fold.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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Rapid change in the use of antiretroviral agents and improvement in a population of HIV-infected patients: France, 1995 to 1997
Article Abstract:
More French physicians are prescribing triple AIDS drug therapy with protease inhibitors and the health of AIDS patients has improved as a result. Researchers used a hospital-based information system to track changes in prescriptions and the health of HIV patients between 1995 and 1997. The number of patients who were treated increased and more were taking two or more drugs. By 1997, protease inhibitors accounted for 40% of the prescriptions. Eighteen months after the introduction of protease inhibitors, the incidence of AIDS dropped 47% and the mortality rate dropped 56%.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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