Sustained-release of estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy

Article Abstract:

Estrogen implants combined with a progestin-releasing intrauterine device worked effectively as postmenopausal replacement therapy. Thirty-six postmenopausal women received one or three estrogen implants, and a levonorgestrel-releasing IUD was inserted. Four women, all with only a single estrogen implant, withdrew from the study because of the return of menopausal symptoms. Three women with three estrogen implants also discontinued therapy. One complained of loss of libido at ten weeks, and another discontinued at 9 months for sensations of swelling. The third woman discontinued at 13 months for uncontrolled bleeding that turned out to be caused by a cervical polyp. By the end of the year-long observation period, 72% of the group had had no bleeding or spotting within the prior three months. This combination of therapies offers the convenience of requiring no daily effort.

Drug therapy, Dosage and administration, Menopause, Progestational hormones, Estradiol

---

Clinical experience with a seven-day estradiol transdermal system for estrogen replacement therapy

Article Abstract:

An estrogen replacement therapy (ERT) consisting of a patch worn for seven days may effectively deliver estrogen while adhering well to the skin. Researchers tested the effects of the Climara transdermal patch in two sizes against those of a twice-weekly patch, conjugated equine estrogens (CEE), and placebo, in 603 postmenopausal women. Both patch sizes and CEE reduced the frequency and severity of hot flushes in seven days of treatment. The larger patch produced relief of symptoms faster, in the first week, than did the smaller patch or CEE. The 7-day patches released estrogen more evenly than did the twice-weekly patch, and adhered to skin much better. The most common reason for stopping treatment was skin irritation from the patch.

Health aspects, Methods, Estrogen, Estrogens

---

Omitting the first oral contraceptive pills of the cycle does not automatically lead to ovulation

Article Abstract:

Ovulation probably will not occur if a woman forgets to take her birth control pills for up to three days. Researchers used ultrasound scans to measure ovulation in 99 women who were randomly assigned to one of three combined oral contraceptive regimens. During an interval of 10 days in which the women did not take their pills, follicle stimulating hormone and estradiol levels increased. This increases the chance of ovulation, but evidence of beginning ovulation was found in only 24% to 40% of the women, depending on which contraceptive regimen they were on.

Usage, Causes of, Oral contraceptives, Ovulation

Similar abstracts:

• Abstracts: The detection and prevention of depression in older people. Nicotine replacement therapy. A nurse-led service to provide information on osteoarthritis
• Abstracts: Assessment of the understanding of the risks and benefits of hormone replacement therapy (HRT) in primary care physicians
• Abstracts: Cord-blood-cell transplantation - a real sleeper? Placental-blood banking - a new frontier in transfusion medicine
• Abstracts: Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. Hemostatic function and coronary artery disease
• Abstracts: Health system reform in the Republic of China: formulating policy in a market-based health system. The Australian health care system: are the incentives Down Under right side up?

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.