Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain

Article Abstract:

A demonstration that Homer1a operates in a negative feedback loop to regulate the excitability of the pain pathway in an activity-dependent manner is presented. Homer 1a is rapidly and selectively upregulated in spinal cord neurons after peripheral inflammation in an NMDA receptor-dependent manner.

United States, Protein research, Chronic pain

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Glucagons-like peptide-1 receptor is involved in learning and neuroprotection

Article Abstract:

Glucagen-like-peptide-1 is a gut peptide, which is expressed in the brain, is discussed in detail. Brain GLP-1R represents a promising new target for both cognitive-enhancing and neuroproctective agents.

Cell receptors

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Learning from the gut

Article Abstract:

Intestinal peptide enhances learning and memory by stimulating insulin secretion from the pancreas. The nerve cells in models of neurodegenerative disorders can also be protected by the peptide.

Usage, Neurodegenerative diseases

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