Synthetic human parathyroid hormone 1-34 vs calcitriol and calcium in the treatment of hypoparathyroidism: results of a short-term randomized crossover trial

Article Abstract:

Synthetic human parathyroid hormone (PTH) 1-34 appears to be more effective than calcitriol in treating a deficiency of parathyroid hormone. Calcitriol is a form of vitamin D, which can correct the deficiency, but often leads to excess calcium in the urine. Researchers gave calcitriol to 10 patients with the deficiency for 10 weeks, then switched them to 10 weeks of PTH 1-34, which contains the active site of the natural hormone. Compared to calcitriol, PTH 1-34 normalized both blood and urine levels of calcium. Excess calcium in urine could lead to kidney stones and other kidney disorders.

Care and treatment, Parathyroid hormone, Parathyroid hormones, Hypoparathyroidism, Calcitriol

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New approaches to the treatment of congenital adrenal hyperplasia

Article Abstract:

Flutamide may be beneficial in the treatment of congenital adrenal hyperplasia (CAH). CAH usually results from a deficiency of the enzyme 21-hydroxylase, which in turn causes a deficiency of cortisol and aldosterone. It also causes an excess production of the male hormone testosterone, which can cause masculinization in young girls. The usual treatment is hydrocortisone, but this drug can have severe side effects. A trial of flutamide in 12 children with CAH showed that this drug could allow doctors to reduce the dose of hydrocortisone in these patients.

Health aspects, Drug therapy, Hydrocortisone, Adrenogenital syndrome, Congenital adrenal hyperplasia, Flutamide

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Hypogonadotropic hypogonadism in a female caused by an X-linked recessive mutation in the DAX1 gene

Article Abstract:

A case is reported of a woman who had hypogonadotropic hypogonadism caused by an X-linked gene mutation. Hypogonadotropic hypogonadism causes delayed puberty. Her two nephews had hypogonadotropic hypogonadism as well as adrenal insufficiency, which is an X-linked disorder caused by a mutation in a gene called DAX1. Normally, women do not develop X-linked diseases. However, the boys' aunt had hypogonadotropic hypogonadism but not adrenal insufficiency. Genetic analysis revealed that she had two copies of the mutation.

Case studies, Hypogonadism

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