Syphilis, neurosyphilis, penicillin, and AIDS
Article Abstract:
Syphilis is a sexually-transmitted disease that is caused by infection with the microorganism known as Treponema pallidum. The first symptoms usually appear within 30 days and include fever and chancroid skin lesions, or ulcers, on the genital organs. During the early stages of disease, the infection can be treated with penicillin. In rare cases, syphilis can reappear and, in the later stages of disease, can spread to the central nervous system. This condition is called neurosyphilis. It can damage the brain and cause loss of memory and the inability to think clearly. Neurosyphilis was very rare in the United States until recently when it began to occur in patients with AIDS. Infection with the human immunodeficiency virus (HIV) causes AIDS. This virus attacks the immune system (the body's natural defense system for fighting infection) and increases the risk for developing life-threatening infections. There have been many reports of neurosyphilis in patients with AIDS; meningitis (inflammation of the brain and spinal cord membranes), nerve abnormalities and strokes have resulted. One study reported that approximately half of the AIDS patients who developed neurosyphilis had been treated with penicillin during the early stages of syphilis. This indicates that penicillin is not effective in preventing neurosyphilis in all patients with AIDS. New methods of preventing and treating neurosyphilis are needed for AIDS patients who develop syphilis. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Infectious Diseases
Subject: Health
ISSN: 0022-1899
Year: 1991
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A 68-year-old man with a 4-week history of undiagnosed fever
Article Abstract:
A case of persistent fever, fatigue and discomfort in a 68-year-old man illustrates the challenge of correctly diagnosing brucellosis infection. Brucellosis is a bacteria transmitted to humans by contact with infected animals. In this case, the patient had recently hunted and slaughtered wild boar. Following infectious disease consultation, the patient was treated with appropriate antibiotics. Brucellosis is best diagnosed by an appropriate exposure history and radioimmunoassay, and treatment should continue for at least six weeks.
Publication Name: Physician Assistant
Subject: Health
ISSN: 8750-7544
Year: 1997
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