T cell costimulation: A rational target in the therapeutic armamentarium for autoimmune diseases and transplantation
Article Abstract:
T cells, the central mediators of adaptive immunity are involved in normal and abnormal immune responses and they need both antigen-specific and costimulatory signals for their full activation. The selective costimulation modulator abatacept binds to CD80 and CD86, jamming interaction with CD28 and is an approved treatment for rheumatoid arthritis, thus the relevant immunology is described and new clinical findings on the two molecules are summarized.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2007
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New concepts in the treatment of rheumatoid arthritis
Article Abstract:
This review describes research advances in the area of rheumatoid arthritis pthogenesis and its impact in revolutionizing the treatment modalities for early early and established rheumatoid arthritis. The therapeutic approaches include aggressive and combination therapy, use of anti-cytokine agents, which retard the joint destruction and delay disability.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2003
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CD4(super+) CD25(super+) regulatory T cells and their therapeutic potential
Article Abstract:
A study is conducted on the therapeutic potential of CD4 and CD25 which are the subset of Tcells, to modulate human immune-based diseases. Results show that CD4 and CD25 play a crucial role in regulating the function of other immune cells and preventing potentially harmful autoimmune responses.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2006
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