T cell-encoded CD80 and 4-1 BBL induce auto- and transcostimulation, resulting in potent tumor rejection
Article Abstract:
Primary human T cells expressing CD80 and 4-1BB ligand (4-1BBL) have responded to tumor cells lacking costimulatory ligands provoking potent rejection of large, systemic tumors in immunodeficient mice. The new strategy of endowing T cells with constitutively expressed costimulatory ligands is used for other ligand-receptor pairs and also for increasing the targeted adoptive transfer therapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
Article Abstract:
Administration of a CD154-specific monoclonal antibody (hu5C8) has been found in a study using nonhuman primates to allow for allotransplantation of kidneys in outbred, MHC-mismatched rhesus monkeys without acute rejection. Therapy with antibody against CD154 is a promising approach for use in human allotransplantation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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