Expansion of rare CD8+CD28-CD11b- T cells with impaired effector functions in HIV-1-infected patients
Article Abstract:
Researchers have discovered increased blood levels of a specific T cell in HIV patients that is unable to kill dangerous microorganisms. In a study of 50 HIV patients, these abnormal cells made up about 20% of all T cells, compared to less than 10% in healthy people.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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CD4+ and CD8+ lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma
Article Abstract:
The CD4+ and CD8+ T lymphocytes of AIDS patients appear to secrete increased amounts of interferon-gamma (IFN-gamma) and the percentage of T cells that secrete IFN-gamma also increases. Researchers took blood samples from 30 HIV-infected injection drug users and seven healthy blood donors. Flow cytometry was used to identify individual T cells that were secreting IFN-gamma and measure the amount of IFN-gamma produced. AIDS patients had a higher percentage of T cells secreting IFN-gamma than the blood donors. This was true despite the fact that their T cell levels fell throughout the study. Even those in the early stages of infection had increased percentages of IFN-gamma-producing T cells. The production of IFN-gamma by T cells increased as the disease progressed. The highest levels occurred in those with advanced disease. Increased IFN-gamma levels could play a role in the immunosuppression seen in AIDS patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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T cells from individuals in advanced stages of HIV-1 infection do not proliferate but express activation antigens in response to HIV-1-specific antigens
Article Abstract:
T cells from AIDS patients appear to be capable of activation but do not proliferate in response to specific antigens. Researchers took blood samples from 23 HIV-infected patients and 15 healthy volunteers and exposed T cells to different antigens, including phytohemagglutinin, staphylococcal enterotoxin B, tetanus toxoid, influenza A virus and several HIV antigens. In the healthy individuals, T cells proliferated in response to all antigens except HIV antigens. In the HIV-infected patients, T cell proliferation was impaired but the T cells expressed CD25 and CD71 activation antigens.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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