TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice

Article Abstract:

The transforming-growth-factor-beta-activated kinase TAK1 is induced in heart muscle by mechanical stress, according to a study in mice. An activating mutation of TAK1 in heart muscle caused symptoms of heart failure, including hypertrophy, myocardial dysfunction, and death.

Research, Protein kinases, Heart failure

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In stroke, complement will get you nowhere

Article Abstract:

Complement may be involved in brain damage caused by stroke and a drug that blocks complement activation may limit such damage. The drug is sCR1sLex, an inhibitor of complement activation bound to a chemical that blocks selectin-mediated cell adhesion.

Physiological aspects, Stroke (Disease), Stroke, Complement (Immunology)

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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

Article Abstract:

Drugs that inhibit the glial membrane water channel aquaporin-4 may reduce brain edema. Mice that were deficient in aquaporin-4 had 35% less cerebral edema following a stroke and better outcomes than mice with intact aquaporin-4.

Health aspects, Prevention, Cerebral edema, Ion channels, Water intoxication, Overhydration

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