Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer

Article Abstract:

This trial demonstrated that the addition of radiation therapy to tomoxifen significantly decreased the rate of local relapse in women 50 years of age or older who had T1 or T2 node-negative breast cancer. 769 women with early breast cancer were randomly assigned to receive breast irradiation plus tamoxifen or tamoxifen alone. As compared with tamoxifen alone, radiotherapy plus tamoxifen significantly reduces the risk of breast and auxiliary recurrence after lumpectomy in women with small, node-negative, hormone-receptor-positive breast cancers.

Health aspects

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Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer

Article Abstract:

Radiation therapy significantly improves local control but not overall survival among women with breast cancer is observed. In women 70 years of age or older and who had clinical stage I, estrogen-receptor-positive breast carcinoma treated by lumpectomy, 636 women were randomly assigned to receive tamoxifen plus radiation therapy or tamoxifen alone. Lumpectomy plus adjuvant therapy with tamoxifen alone is a realistic choice for the treatment of women 70 years of age or older who have early estrogen-receptor-positive breast cancer.

Science & research, Research, Lumpectomy

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Risk and benefits of phase 1-oncology trials, 1991 through 2002

Article Abstract:

The Cancer Therapy Evaluation Program at the National Cancer Institute that sponsored a nonpediatric phase 1 oncology trails between 1991 and 2002 was reviewed. The rates of response of treatment, of stable disease, of grade 4 toxic events, and of treatment-related deaths were reported.

United Kingdom, Labor Distribution by Employer, Mortality, Statistics, Cancer

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