The autoimmune regulator (Aire) controls iNKT cell development and maturation

Article Abstract:

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) is attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It is postulated that Aire is involved in development of regulatory T Cells, and it is shown that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for INKT cells in APS1.

Research, United States, Autoimmunity, Epithelial cells, Autoantigens

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CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia

Article Abstract:

Blocking the thrombospondin receptor CD47 with a monoclonal antibody appears to cause apoptosis in B-cell chronic lymphocytic leukemia cells. This effect does not involve caspase, and could be an effective treatment for an incurable disease.

Health aspects, Care and treatment, Monoclonal antibodies, Lymphocytic leukemia

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Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1

Article Abstract:

Some tumors produce an antigen called RCAS1, which destroys any lymphocytes containing the RCAS1 receptor. This may be one way tumors evade the immune system.

Causes of, Physiological aspects, Cell death, Tumor antigens

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