The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1

Article Abstract:

The body naturally produces a protein that blocks the interleukin-1 receptor. Interleukin-1 stimulates inflammation and the receptor blocker has an anti-inflammatory effect. If the body doesn't produce enough of the interleukin-1 receptor blocker, doctors can give patients with inflammatory diseases extra amounts of the protein.

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The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells

Article Abstract:

The influence of a diet supplement of n-3 fatty acids on the body's ability to synthesize interleukin-1 and tumor necrosis factor (TNF), cytokines produced in response to injury, tumorous growth, or other challenges to the immune system, is examined. Polyunsaturated n-3 fatty acids are commonly found in cold-water fish and seal meat and are not a normal part of the Western diet, but they comprise a large portion of the dietary fatty acids consumed by the Japanese, Eskimos, and Dutch in the form of fish. The consumption of n-3 fatty acids is associated with a lower incidence of cardiovascular and inflammatory diseases. Dietary supplementation with n-3 fatty acids reduces the level of interleukin-1 and TNF production and may contribute to the decreased inflammatory responses, although the means by which this occurs is not known.

Health aspects, Research, Analysis, Usage, Interleukins, Dietary supplements, Nutritional aspects, Cytokines, Tumor necrosis factor, Radioimmunoassay, Unsaturated fatty acids, Unsaturated fatty acids in human nutrition

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The role of interleukin-1 in disease

Article Abstract:

Interleukin-1 appears to play a critical role both in maintaining the body's defense mechanisms and in mediating disease. The interleukin-1 family is comprised of two agonists, alpha and beta, and a receptor antagonist which blocks the effects of interleukin-1 alpha and beta. Interleukin-1's role in host defense includes stimulating the production of T and B white blood cells. Interleukin-1 has been associated with the development of a number of diseases including including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. It also appears to stimulate growth of acute and chronic myelogenous leukemia cells and to destroy the insulin-secreting beta cells in patients with insulin-dependent diabetes. It directly induces septic shock, but in autoimmune diseases such as insulin-dependent diabetes acts as an intermediary, not as an initiator. Increased levels of interleukin-1-receptor antagonist in patients with various diseases have led to studies on its therapeutic use, and early results suggest it may be both safe and effective.

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