The effect of lipid peroxides on isolated human umbilical artery contraction

Article Abstract:

Oxidized lipids do not appear to alter the contractility of human umbilical arteries. Damage to the cells lining blood vessels is believed to play a role in the clinical signs and symptoms of pregnancy-induced hypertension. One likely cause of the damage is oxidative stress caused by highly reactive compounds such as lipid peroxide. Blood levels of lipid peroxides are elevated in hypertensive pregnancies, and lipid peroxides have previously been shown to cause blood vessel constriction. In a study, artery ring segments were removed from human umbilical cords at birth and placed in titered solutions. Contractility was measured in the presence of lipid peroxidase, U46619 and CA++ solutions. No effects were found for lipid peroxidase. The contractile response was lessened in the other solutions.

Lipid peroxidation

---

Human umbilical vessels: responses to agents frequently used in obstetric patients

Article Abstract:

Drugs given to pregnant women to control high blood pressure may differ in their ability to dilate the vessels of the umbilical cord. High blood pressure drugs may work differently in the mother than they do in the fetus. Researchers conducted a laboratory analysis of the effects of magnesium sulfate, hydralazine, phenytoin, and several dihydropyridine calcium channel blockers on segments of umbilical cords after delivery. All of the drugs were found to dilate the umbilical cord smooth muscle except for hydralazine. Hydralazine may dilate the blood vessels of the mother but not of the fetus, which may cause a problem to the fetus. Calcium channel blockers, especially nifedipine, worked the most powerfully to dilate the umbilical vessels.

Blood vessels, Umbilical cord

---

Meconium inhibits the contraction of umbilical vessels induced by the thromboxane A2 analog U46619

Article Abstract:

Meconium may not cause umbilical vessels to contract, but instead may inhibit contraction. Researchers studied the effect of meconium, or fetal bowel movement, on umbilical cords after delivery from 16 normal pregnancies. Rings of umbilical cord containing either the artery or vein were exposed to a 1% meconium solution. Meconium did not cause the umbilical artery or vein to contract. U46619, a constricting agent, was added to the solution, and meconium inhibited its ability to cause the umbilical artery and vein to contract. The fatty substance of meconium may be its inhibiting factor. The presence of meconium in amniotic fluid may not cause constriction of umbilical vessels that in turn could harm the fetus.

Analysis, Amniotic fluid, Meconium

Similar abstracts:

• Abstracts: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. The hydrogen highway to reperfusion therapy
• Abstracts: The effect of link nurses on hospital readmission rates. 'Cannabis can compound mental health problems'
• Abstracts: The effect of maternal oxygen administration during the second stage of labor on umbilical cord blood gas values: a randomized controlled prospective trial
• Abstracts: The effectiveness of video-based interventions in promoting condom acquisition among STD clinic patients. Reductions in STD infections subsequent to an STD clinic visit: using video-based patient education to supplement provider interactions
• Abstracts: Associations between HLA and antibodies to collagen in rheumatoid arthritis. Shared amino acid sequences between major histocompatiblity complex class II glycoproteins, type XI collagen and Proteus mirabilis in rheumatoid arthritis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.