The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model
Article Abstract:
A growth factor may change the steroid production of ovaries that are cancerous by inhibiting an important enzyme known as P450c17. Researchers obtained tumor cells from thecal cells of the human ovary and exposed them to transforming growth factor-beta-1 (TGF-beta-1). TGF-beta-1 was found to inhibit steroid production of cancerous ovarian thecal cells by inhibiting the enzyme P450c17. TGF-beta-1 may act locally on ovarian thecal cells to inhibit production of the steroid androstenedione. TGF-beta-1 inhibition of the activity of the enzyme P450c17 may impair estrogen formation. It may also increase progesterone secretion. TGF-beta-1 inhibited forskolin and 17-hydroxyprogesterone and dehydroepiandrosterone secretion as well as P450c17. Its effects may vary among different mammals.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Characteristics of antigens from an HCG-alpha secreting cell line (ElCo) derived from human breast carcinoma in a Native American patient
Article Abstract:
Establishing cancer cell cultures from women of different races could allow researchers to determine if there are racial variations in the cells' characteristics. Researchers established a cell culture from breast cancer cells taken from a Native American woman and studied it. The cells displayed a characteristic enzyme found more commonly in minority populations. The cells also caused antibody reactions when incubated with white blood cells taken from other women with breast cancer, and they secreted an unusual form of human chorionic gonadotropin alpha, a known marker for breast cancer cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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PTEN/MMAC1 mutations correlate inversely with an altered p53 tumoe suppressor gene in gynecologic tumors
Article Abstract:
Mutations in the p53 tumor suppressor gene may cause many types of gynecologic cancer, including cervical cancer, ovarian cancer, and uterine cancer. These mutations may occur in the PTEN/MMAC1 portion of the gene, according to a study of Chinese and African-American women.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2003
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