The incidence of the factor V Leiden mutation in an obstetric population and its relationship to deep vein thrombosis

Article Abstract:

The prevalence of factor V Leiden mutation among childbearing women may indicate the need for prenatal genetic testing to detect the mutation. Presence of the factor V Leiden mutation predisposes women to developing blood clots. Researchers tested DNA from the blood of 407 women who comprised a low-risk obstetric population. Fourteen women (3%) carried the Leiden mutation, and four of these women (28%) developed blood clots in the deep veins. Another woman with the mutation experienced a depletion of clotting factors leading to vaginal bleeding. She required delivery at 20 weeks of pregnancy.

Analysis, Physiological aspects, Thrombosis, Deep vein, Deep vein thrombosis, Protein C

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Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction

Article Abstract:

Mothers who carry the factor V Leiden genetic mutation appear to be at increased risk for miscarriage or blood clots in the placenta. Blood samples from 139 mothers with spontaneous miscarriages, 396 mothers with placental blood clots, and 403 mothers with routine deliveries were analyzed for the factor V Leiden mutation. Women with blood clots covering more than 10% of the placenta were 10 times more likely to carry the mutation than those with less widespread clotting. Women who had miscarried were twice as likely to carry the mutation as those with routine deliveries.

Miscarriage, Infarction, Placental diseases, Placenta diseases

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The factor V Leiden mutation may predispose women to severe preeclampsia

Article Abstract:

Women with a mutation of a factor in the clotting pathway may be more likely to develop severe preeclampsia. Researchers analyzed DNA from blood samples from 158 pregnant women with severe preeclampsia and compared results with 403 pregnant women with normal blood pressure. Nine percent of the preeclamptic women had one abnormal factor V gene versus 4% of the healthy women. Persons with this mutation are prone to form clots, and women with this mutation may be prone to forming clots within the placenta, which then triggers the events leading to preeclampsia.

Preeclampsia

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